| 多组份一锅法合成新型2-取代噻唑-4-甲酸衍生物 |
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| 引用本文： | 邓兰青.多组份一锅法合成新型2-取代噻唑-4-甲酸衍生物[J].合成化学,2014,22(5):643-646. |
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| 作者姓名： | 邓兰青 |
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| 作者单位： | 岳阳职业技术学院岳阳市中草药综合利用重点实验室,湖南岳阳414000;中南大学化学化工学院,湖南长沙410083 |
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| 摘 要： | 以甲醇为溶剂,以醛、胺、硫代乙酸和3-(二甲氨基)-2-异氰基丙烯酸甲酯为原料,经四组份一锅法反应合成了9个新型的2-取代噻唑-4-甲酸衍生物,产率25%~54%,纯度90.3%~100%,其结构经1H NMR,13C NMR和LC-MS表征。
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| 关 键 词： | 醛 胺 异腈 硫代乙酸 2-取代噻唑-4-甲酸 合成 一锅法 |
Synthesis of Novel 2-Substituted Thiazole-4-carboxylic Acid Derivatives by Multicomponent One-pot Reaction |
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| DENG Lan-qing.Synthesis of Novel 2-Substituted Thiazole-4-carboxylic Acid Derivatives by Multicomponent One-pot Reaction[J].Chinese Journal of Synthetic Chemistry,2014,22(5):643-646. |
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| Authors: | DENG Lan-qing |
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| Institution: | DENG Lan-qing;Key Laboratory of Yueyang Chinese Herbal Utilization,Yueyang Vocational Technical College;School of Chemistry and Chemical Engineering,Central South University; |
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| Abstract: | |
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| Keywords: | aldehyde amine thioacetic acid isonitrile 2-substituted thiazole-4-carboxylic acid synthesis one-pot |
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