Selected ion monitoring for the determination of bromovalerylurea in human plasma. |
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Authors: | J Kokatsu R Yomoda T Suwa |
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Affiliation: | Research Center, Taisho Pharmaceutical Co., Ltd., Saitama, Japan. |
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Abstract: | A gas chromatography-selected ion monitoring procedure with chemical ionization is described for the determination of bromovalerylurea (BVU) in human plasma. BVU was extracted with ether after addition of 2-bromo-2-methylpropylurea as an internal standard. The lower limit of BVU quantification by this method was 2 ng/0.1 ml plasma volume. This procedure was used to determine the sequential plasma levels of BVU in a human volunteer following a single oral dose of a commercial analgesic. |
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