羧基化氧化石墨烯的可控合成及血液相容性

采用自由基引发剂偶氮二异丁腈(AIBN)作为功能改性剂, 通过AIBN分解产生的异丁腈自由基进攻氧化石墨烯上五元环与七元环的缺陷点, 形成氰基改性氧化石墨烯中间体, 再通过水解反应制得羧基化氧化石墨烯[GeneO-C(CH₃)₂-COOH]纳米材料. 采用傅里叶变换红外光谱(FTIR), X射线衍射(XRD), 热重分析(TGA)和原子力显微镜(AFM)等方法对合成的材料进行了表征, 并采用复钙时间测试考察了材料的血液相容性. 研究结果表明, 氧化石墨烯中羧基的含量可以通过调整AIBN和GeneO的投料比来控制. 本方法不但可提高氧化石墨烯的羧基含量, 而且可使其具有良好的血液相容性.

Controlled Synthesis and Blood Compatibility Properties of Carboxyl Graphene Oxide

Carboxyl modifiedgraphene oxide is important in the preparation of functionalized graphene oxide(GeneO). In this work, the free radical initiator agent azobisisobutyronitrile(AIBN) was functioned as a modifier. AIBN could be separated into isobutyronitrile radicals to attack the five-membered ring and seven-membered ring defects in the graphene oxide. Then the cyanogroup-modified graphene oxide intermediates were formed, and the carboxyl graphene oxide [GeneO-C(CH3)2-COOH] could be obtained through the hydrolysis reaction. The structure and properties of GeneO-C(CH3)2-COOH were characterized by Fourier transform infrared spectroscope(FTIR), X-ray diffraction(XRD), thermo gravimetric analyzer(TGA) and atomic force microscope(AFM). And the blood compatibility of GeneO-C(CH3)2-COOH was evaluated by recalcification time test. It was showed that the recalcification time gradually decreased as the increasing concentration of GeneO-C(CH3)2-COOH, indicating that the material had good blood compatibility. Carboxyl group content could be controlled by the mass ratio of AIBN to GeneO. This method not only could increase the carboxyl content of oxidized graphene, but also made the material have a good blood compatibility.