Rapid hydrolytic cleavage of the mRNA model compound HPNP by glycine based macrocyclic lanthanide ribonuclease mimics |
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| Authors: | Gunnlaugsson Thorfinnur Davies R Jeremy H Nieuwenhuyzen Mark Stevenson Clarke S Viguier Romain Mulready Sinead |
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| Affiliation: | Department of Chemistry, Trinity College Dublin, Dublin 2, Ireland. gunnlaut@tcd.ie |
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| Abstract: | The lanthanide ion based macrocyclic complexes 1.Ln mimic the hydrophobic nature of ribonucleases, where the lanthanide ions induce the formation of a hydrophobic cavity for 1, giving rise to a large order of magnitude enhancement in the hydrolytic cleavage of HPNP. |
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