A new synthesis of phosphoramidates: inhibitors of the key bacterial enzyme aspartate semi-aldehyde dehydrogenase |
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| Authors: | Adams Luke A Cox Russell J Gibson Jennifer S Mayo-Martín M Belén Walter Magnus Whittingham William |
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| Affiliation: | School of Chemistry, University of Bristol, Cantock's Close, Bristol, UK BS8 1TS. |
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| Abstract: | A new, mild and high yielding synthesis of phosphoramidates is described: potassium salts of carboxylic acids are treated with ethylchloroformate and the resulting activated anhydride-carbonates are then treated with LiNH-P(O)(OEt)2 in situ--the methodology is especially suited to acid sensitive systems featuring BOC, tBu or acetal protecting groups. |
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