Wet sol–gel silica matrices as delivery devices for phenytoin |
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Authors: | Alexandra Fidalgo Tessy M Lopez Laura M Ilharco |
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Institution: | (1) CQFM—Centro de Química-Física Molecular and IN—Institute of Nanoscience and Nanotechnology, Instituto Superior Técnico, Universidade Técnica de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisbon, Portugal;(2) Universidad Autónoma Metropolitana-Xochimilco, Calzada del Hueso 1100, Tlalpan, C. P. 04960 México, D.F, México;(3) Instituto Nacional de Neurología y Neurocirugía “MVS”, Insurgentes Sur 3877, Col. La Fama, C. P. 14269 México, D.F, México |
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Abstract: | Wet sol–gel silica matrices produced under different hydrolysis conditions were used as delivery devices to the active principle
of an antiepileptic drug (phenytoin sodium), encapsulated during the condensation stage. Post-incorporation into dry silica
powder was an alternative loading procedure. It was proven by infrared spectroscopy that neither the silica network nor the
drug loose integrity by encapsulation. The kinetics of in vitro drug release was studied at 37 °C, to water and to artificial
cerebrospinal fluid (ACSF). Emphasis has been given to the release to ACSF under dynamic conditions (with fluid renovation,
emulating what occurs in the brain). Different delivery regimes were identified and correlated with the loading method and
the matrix structure. Matrices with lower total porosity and smaller average pore size proved to be better for a long term
release. Renovation of ACSF is relevant to assure a constant concentration of phenytoin in the vicinity of the device. |
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Keywords: | Sol– gel silica Phenytoin sodium UV-Vis spectroscopy Diffuse reflectance infrared spectroscopy |
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