Allene-alkyne cross-coupling for stereoselective synthesis of substituted 1,4-dienes and cross-conjugated trienes |
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| Authors: | Shimp Heidi L Hare Alissa McLaughlin Martin Micalizio Glenn C |
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| Institution: | Department of Chemistry, Yale Univeristy, New Haven, Connecticut 06520-8107. |
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| Abstract: | Titanium-mediated cross-coupling of allenic alcohols with alkynes has been investigated. Divergent reaction pathways were discovered that provide either stereodefined 1,4-dienes or substituted cross-conjugated trienes. In short, allene substitution plays a critical role in the determination of reaction pathway. |
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