| 基于太赫兹技术的药物检测 |
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| 引用本文： | 段瑞鑫, 赵红卫, 朱亦鸣. 基于太赫兹技术的药物检测[J]. 物理, 2013, 42(11): 781-787. DOI: 10.7693/wl20131103 |
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| 作者姓名： | 段瑞鑫 赵红卫 朱亦鸣 |
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| 作者单位： | 1.(1 上海理工大学上海市现代光学系统重点实验室上海200093);2.(2 中国科学院上海应用物理研究所上海201800) |
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| 基金项目： | 上海市基础研究重点项目(批准号12JC1407100)；国家重大科学仪器专项基金，国家自然科学基金(批准号11174207，61138001，61007059，61205094)资助项目；上海市教育委员会重点学科建设基金 |
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| 摘 要： | 鉴于太赫兹辐射特有的光谱分辨性、功能性成像特点以及良好的穿透性和安全性等，太赫兹波谱技术迅速成为物质分析与检测等的重要工具。文章基于太赫兹时域光谱技术的实验数据，结合泛函密度理论(DFT)和HIPHOP模型，对一系列降糖类药物进行分子解析和功能基团识别；结合支持向量机理论(SVM)，对4种郁金类中草药进行分析识别；并结合差式扫描量热法对葡萄糖—水合物的结晶水状态进行测定；最后对太赫兹时域技术在药物检测方面的优势和不足做了进一步的分析与展望。
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| 关 键 词： | 太赫兹 药物检测 中草药 降糖药 葡萄糖 |
| 收稿时间： | 2013-11-12 |
| 修稿时间： | 2013-11-12 |
Drug detection by terahertz time-domain spectroscopy |
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| DUAN Rui-Xin, ZHAO Hong-Wei, ZHU Yi-Ming. Drug detection by terahertz time-domain spectroscopy[J]. PHYSICS, 2013, 42(11): 781-787. DOI: 10.7693/wl20131103 |
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| Authors: | DUAN Rui-Xin ZHAO Hong-Wei ZHU Yi-Ming |
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| Affiliation: | 1.(1 Engineering Research Center of Optical Instrument and System，University of shanghai for Science and Technology，Shanghai 200093，China);2.(2 Shanghai Institute of Applied Physics，Chinese Acdemy Sciences，Shanghai 201800，China) |
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| Abstract: | Due to unique spectral region, functional imaging ability, excellent penetration and safety characteristics of terahertz radiation, the terahertz technology rapidly becomes a vital method to detect and analyze drugs. In this paper, firstly, we identify the functional groups of anti-diabetic drugs by density functional theory (DFT), HIPHOP models and experimental results from terahertz time-domain spectroscopy measurements. Secondly, we identify four kinds of herbs of radix curcumae by using the support vector machine (SVM) analysis. Besides, we analyze the absorption of anhydrous and hydrous glucose, and determine the state of water in the crystalized D-glucose·H2O through the results of differential scanning calorimetry measurement. Finally, we summarize the advantages and disadvantages of terahertz time-domain spectroscopy method in drug detection and analyzation. |
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| Keywords: | terahertz drug detection herbs anti-diabetes glucose |
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