1H and 13C NMR assignments of three nitrogen containing compounds from the mangrove endophytic fungus (ZZF08) |
| |
Authors: | Tao Yiwen Zeng Xianjian Mou Chengbo Li Jun Cai Xiaoling She Zhigang Zhou Shining Lin Yongcheng |
| |
Institution: | School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, 510275, PR China. |
| |
Abstract: | A new natural product, named phomopsin A, 1-(meta-hydroxyphenyl)-4-hydroxy-3-isoquinolone (1), together with two known compounds cytochalasin H (2) and glucosylceramide (3), was isolated from the mangrove endophytic fungus Phomopsis sp. (ZZF08) obtained from the South China Sea coast. The structures were elucidated by 1D and 2D NMR experiments including COSY, HMQC, and HMBC. According to NMR and single-crystal X-ray diffraction, it was found that some assignments about (1)H and (13)C NMR data for cytochalasin H (2) were probably uncorrected in the previous reports. In our cytotoxicity assays, compound 1 showed moderate cytotoxicity toward KB cells with IC(50) at 28.0 microg ml(-1) and KBv200 cells with IC(50) at 16.8 microg ml(-1), and compound 2 exhibited strong cytotoxicity toward KB cells and KBv200 cells with IC(50) less than 1.25 microg ml(-1). |
| |
Keywords: | NMR 1H NMR 13C NMR 2D NMR isoquinolone cytochalasin H glucosylceramide structure elucidation cytotoxicity |
本文献已被 PubMed 等数据库收录! |
|