Double diastereoselective SuperQuat glycolate aldol reactions: application to the asymmetric synthesis of polyfunctionalised lactones |
| |
| Authors: | Davies Stephen G Nicholson Rebecca L Smith Andrew D |
| |
| Institution: | The Department of Organic Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK. steve.davies@chem.ox.ac.uk |
| |
| Abstract: | Polyfunctionalised lactones with up to five contiguous stereocentres may be prepared with high stereocontrol by a double diastereoselective aldol protocol with protected homochiral alpha,beta-dihydroxy- or alpha,beta-gamma-trihydroxyaldehydes and a chiral glycolate oxazolidinone, followed by subsequent O-desilylation and lactonisation. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
