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Modiolin and phthalide derivatives from the endophytic fungus Microsphaeropsis arundinis PSU-G18 |
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| Authors: | Ubonta SommartVatcharin Rukachaisirikul Kwanruthai TadpetchYaowapa Sukpondma Souwalak PhongpaichitNongporn Hutadilok-Towatana Jariya Sakayaroj |
| Institution: | a Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand b Natural Products Research Center and Department of Microbiology, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand c Department of Biochemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand d National Center for Genetic Engineering and Biotechnology, Thailand Science Park, Klong Luang, Pathumthani 12120, Thailand |
| Abstract: | One new modiolin, microsphaerodiolin (1), and seven new phthalides, microsphaerophthalides A-G (2-8), together with 12 known compounds were isolated from the endophytic fungus Microsphaeropsis arundinis PSU-G18. Their structures were elucidated by spectroscopic methods. The new 3-oxygenated phthalides are rare natural products. The known 1-(2,5-dihydroxyphenyl)-2-buten-1-one exhibited significant antifungal activity against Microsporum gypseum SH-MU-4 with an MIC value of 8 μg/mL, moderate antimalarial activity with an IC50 value of 9.63 μg/mL and strong radical scavenging potency with the IC50 value of 0.018 mg/mL. The new compounds 2 and 6 showed moderately antifungal activity against M. gypseum SH-MU-4 and Cryptococcus neoformans, respectively, with equal MIC values of 64 μg/mL. |
| Keywords: | Endophytic fungus Microsphaeropsis arundinis Phthalide derivatives Antifungal Antimalarial Antioxidant |
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