Direct Enantioselective Vinylogous Mannich Reaction of Ketimines with γ‐Butenolide by Using Cinchona Alkaloid Amide/Zinc(II) Catalysts |
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| Authors: | Prof?Dr Shuichi Nakamura Ryota Yamaji Dr Masashi Hayashi |
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| Institution: | Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa‐ku, Nagoya 466‐8555 (Japan), Fax: (+81)?52‐735‐5245http://www.ach.nitech.ac.jp/～organic/nakamura/index.html |
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| Abstract: | A direct enantioselective vinylogous Mannich reaction of ketimines with γ‐butenolide has been developed. Good yields and enantioselectivities were observed for the reaction of various ketimines by using a cinchona alkaloid amide/Zn(OTf)2 catalyst and Et3N. Both enantiomers of the products could be obtained by using pseudoenantiomeric chiral catalysts. |
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| Keywords: | asymmetric synthesis cinchona alkaloids ketimines Lewis acids γ ‐butenolides |
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