Palladium‐Catalyzed Three‐Component Cascade Reaction: Facial Access to Densely Functionalized Indolizines |
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| Authors: | Ren‐Rong Liu Chuan‐Jun Lu Ming‐Di Zhang Jian‐Rong Gao Prof?Dr Yi‐Xia Jia |
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| Institution: | College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014 (P. R. China) |
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| Abstract: | A palladium‐catalyzed three‐component cascade reaction of 2‐(2‐enynyl)pyridines with nucleophiles and allyl halides has been developed, enabling the synthesis of densely functionalized indolizines in moderate to good yields. The newly developed methodology offers several practical advantages, including operational simplicity, ready availability of starting materials, and mild reaction conditions. |
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| Keywords: | cascade reactions cyclization enynes heterocycles palladium |
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