Iron‐Catalyzed C(sp2)H and C(sp3)H Methylations of Amides and Anilides |
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| Authors: | Karolina Graczyk Tobias Haven Prof Dr Lutz Ackermann |
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| Institution: | Institut für Organische und Biomolekulare Chemie, Georg‐August‐Universit?t G?ttingen, Tammannstra?e 2, 37077 G?ttingen (Germany) http://www.ackermann.chemie.uni‐goettingen.de/ |
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| Abstract: | The so‐called magic methyl effect significantly boosts the bioactivities and physical properties of pharmacologically active drugs. Direct introduction of the methyl group by C?H activation was accomplished with a versatile iron catalyst, which enabled the C?H methylation of (hetero)benzamides, anilides, alkenes, and even alkanes by triazole assistance in a chemo‐, site‐ and diastereo‐selective fashion. |
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| Keywords: | amides C H activation drug design iron synthetic methods |
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