Dienamine and Friedel–Crafts One‐Pot Synthesis,and Antitumor Evaluation of Diheteroarylalkanals |
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| Authors: | María Frías Dr José M Padrón Dr José Alemán |
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| Institution: | 1. Organic Chemistry Department, Universidad Autónoma de Madrid, 28049 Madrid (Spain) www.uam.es/jose.aleman;2. Instituto Universitario de Bio‐Orgánica, ?Antonio González“ (IUBO‐AG), Centro de Investigaciones Biomédicas de Canarias (CIBICAN), Universidad de La?Laguna, 38206 La?Laguna (Spain) |
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| Abstract: | An asymmetric synthesis of diheteroarylalkanals through one‐pot dienamine and Friedel–Crafts reaction is presented. The reaction tolerates a large variety of substituents at different positions of the starting aldehyde and also in the indole nucleophile, and a range of diheterocyclic alkanals can be achieved. Furthermore, we have studied the antiproliferative activity of these new compounds in representative cancer tumor cell lines. |
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| Keywords: | aldehydes antiproliferation asymmetric synthesis nitrogen heterocycles organocatalysis |
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