Transition‐Metal‐Free Trifluoromethylthiolation of N‐Heteroarenes |
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| Authors: | Prof. Dr. Frank Glorius |
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| Affiliation: | Organisch‐Chemisches Institut, Westf?lische Wilhelms‐Universit?t Münster, Corrensstra?e 40, 48149 Münster (Germany) |
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| Abstract: | A general and efficient methodology for the direct transition metal free trifluoromethylthiolation of a broad range of biologically relevant N‐heteroarenes is reported employing abundant sodium chloride as the catalyst. This method is operationally simple, exhibits high functional group tolerance, and does not require protecting groups. |
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| Keywords: | electrophilic substitution N‐heterocycles sodium chloride synthetic methods trifluoromethylthiolation |
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