Absolute Asymmetric Synthesis: Viedma Ripening of [Co(bpy)3]2+ and Solvent‐Free Oxidation to [Co(bpy)3]3+ |
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| Authors: | Per Martin Björemark Johan Jönsson Prof. Mikael Håkansson |
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| Affiliation: | Department of Chemistry and Molecular Biology, University of Gothenburg, 412 96 Gothenburg (Sweden) |
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| Abstract: | Syntheses of [Co(bpy)3]2+ yield racemic solutions because the Δ‐ and Λ‐enantiomers are stereochemically labile. However, crystallization and attrition‐enhanced deracemization can give homochiral crystal batches of either handedness in quantitative yield. Subsequently, solvent‐free oxidation with bromine vapour fixes the chirality because [Co(bipy)3]3+ does not enantiomerize in solution at ambient temperature. This combination of Viedma ripening and the labile/inert CoII/CoIII couple constitutes a convenient method of absolute asymmetric synthesis. |
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| Keywords: | asymmetric synthesis circular dichroism cobalt deracemization structure elucidation |
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