Cobalt‐Catalyzed CH Arylations with Weakly‐Coordinating Amides and Tetrazoles: Expedient Route to Angiotensin‐II‐Receptor Blockers |
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| Authors: | Jie Li Prof?Dr Lutz Ackermann |
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| Institution: | Institut für Organische und Biomolekulare Chemie, Georg‐August‐Universit?t G?ttingen, Tammannstrasse?2, 37077 G?ttingen (Germany) http://www.ackermann.chemie.uni‐goettingen.de/ |
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| Abstract: | Cobalt‐catalyzed C?H arylations enabled the synthesis of biaryl tetrazoles, which are key structural motifs in antihypertensive angiotensin‐II‐receptor blockers. Thus, weakly‐coordinating benzamides were employed for step‐economical C?H arylations with ample scope. Further, a low‐valent NHC complex enabled first cobalt‐catalyzed C?H functionalization by tetrazole assistance. |
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| Keywords: | amides arylation C H activation cobalt tetrazoles |
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