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Saccharin‐Based μ‐Oxo Imidoiodane: A Readily Available and Highly Reactive Reagent for Electrophilic Amination |
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| Authors: | Dr. Akira Yoshimura Steven R. Koski Jonathan M. Fuchs Prof. Dr. Akio Saito Prof. Dr. Victor N. Nemykin Prof. Dr. Viktor V. Zhdankin |
| Affiliation: | 1. Department of Chemistry and Biochemistry, University of Minnesota Duluth, Duluth, MN 55812 (USA) http://www.d.umn.edu/～vzhdanki/;2. Division of Applied Chemistry, Institute of Engineering, Tokyo University of Agriculture and Technology, 2‐24‐16 Naka‐cho, Koganei, Tokyo 184‐8588 (Japan) |
| Abstract: | Three new saccharin‐based hypervalent iodine compounds were prepared by the reaction of saccharine with (diacetoxyiodo)arenes or acetoxybenziodoxole. Structures of these new imidoiodanes were established by X‐ray crystallography. The saccharin‐based μ‐oxo‐bridged imidoiodane readily reacts with silyl enol ethers under mild conditions to give the corresponding α‐aminated carbonyl compounds in moderate yields. |
| Keywords: | amination hypervalent iodine oxidation saccharin |