Highly efficient synthesis of peptides by rational utilization of novel coupling reagents |
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| Authors: | LI Peng XU Jie-Cheng |
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| Affiliation: | LI,Peng XU,Jie-ChengShanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China |
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| Abstract: | The efficiency of different peptide coupling reagents, including carbodiimides, HOBt or HOAt-derived uronium, phosphoni-um and immonium salts, halouronium, halophosphonium, 2-halopyridinium and 2-halothiazoliuim salts, was evaluated. The synthetic strategy for coded peptides andnonribosomal peptides was discussed with an emphasis on the rational selection of peptide coupling reagents. |
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| Keywords: | Peptide coupling reagent racemization reactivi-ty nonribosomal amino acid |
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