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Chiral guanidine catalyzed Michael addition reaction and Diels-Alder reaction of anthrone and N-methylmaleimide |
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| Authors: | PENG Bin CHENG Ke-Jun MA Da-Wei |
| Institution: | PENG,Bin CHENG,Ke-Jun MA,Da-Wei Department of Chemistry,Fudan University,Shanghai 200433,ChinaState Key Laboratory of Bioorganic and Natural Products Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,354 Fenglin Lu,Shanghai 200032,China |
| Abstract: | Two chiral guanidines were evaluated as catalysts for the reaction of anthrone (1) with N‐methylmaleimide (2). When guanidine 5 was used, the Michael adduct 4 was isolated as a major product. The best enantioselectivity (70% ee) was obtained when the reaction was carried out in THF at ‐20°C. |
| Keywords: | Chiral catalysts guanidine cycloaddition michael addition |
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