An efficient total synthesis of (−)-anamarine |
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Authors: | Palakuri RameshHM Meshram |
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Institution: | Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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Abstract: | An efficient synthesis of (−)-anamarine is described using d(+)-mannitol and (R)-epichlorohydrin. The synthesis is achieved starting from easily accessible d(+)-mannitol using a selective benzoylation, regioselective epoxide ring opening, a selective acetonide deprotection, tosylation and cross metathesis reaction. |
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Keywords: | Mannitol (R)-Epichlorohydrin Tosylation Lactonization Cross metathesis Grubb&rsquo s catalyst |
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