Facile synthesis and in vivo bioimaging applications of porphyrin derivative-encapsulated polymer nanoparticles |
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| Institution: | 1. Guangdong Provincial Engineering and Technology Center of Advanced and Portable Medical Devices, School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China;2. State Key Laboratory of Oncology in South China, Collaborative Innovation Center For Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510060, China;3. Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China |
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| Abstract: | Fluorescence (FL) imaging guided photodynamic therapy (PDT) is becoming highly desirable for personalized therapy and precision medicine. In this study, fluorescent polymer nanoparticles TCPP@PEI/PGA were facilely synthesized through electrostatic interaction-mediated self-assembly of porphyrins tetra(4-carboxyphenyl)porphine (TCPP) and polyethylenimine (PEI), and subsequent surface modification with γ-poly(glutamic acid) (γ-PGA). TCPP served a dual function as the FL imaging probe and the photosensitizer. The as-prepared TCPP@PEI/PGA nanoparticles showed excellent water-solubility and biocompatibility, while having outstanding capabilities of in vivo bioimaging and 1O2 generation. FL bioimaging of mice and effective killing of CT 26 cells as well as CT 26 tumor-bearing mice upon laser irradiation were successfully demonstrated when using TCPP@PEI/PGA as theranostic nanoprobes. This study provides a simple but robust method to design and synthesize porphyrin-based polymer nanoparticles for theranostics. |
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