Visible-light-irradiated tandem sulfonylation/cyclization of indole tethered alkenes for the synthesis of tetrahydrocarbazoles |
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| Affiliation: | Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China |
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| Abstract: | A visible-light-mediated reaction of indole derivatives employing arylsulfonyl chlorides as sulfonyl surrogates has been developed, which proceeds via the sequence of reduction of sulfonyl chloride, sulfonylation, and intramolecular cyclization. This mild protocol transforms a diverse array of indole tethered alkenes and simple sulfonyl chlorides into highly valuable functionalized tetrahydrocarbazoles in good yields. This reaction is also suitable for gram-scale synthesis, which provides an efficient and green access to multi-substituted tetrahydrocarbazoles. |
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