A multifunctional upconversion nanoparticles probe for Cu2+ sensing and pattern recognition of biothiols |
| |
| Institution: | 1. School of Chemistry and Molecular Engineering, Shanghai Key Laboratory for Urban Ecological Processes and Eco-Restoration, East China Normal University, Shanghai 200241, China;2. Fujian Provincial Key Laboratory of Resources and Environment Monitoring & Sustainable Management and Utilization, College of resource and chemical engineering, Sanming University, Sanming 365004, China |
| |
| Abstract: | Lanthanide-doped upconversion nanoparticles (Ln-UCNPs) are a new type of nanomaterials with excellent fluorescence properties, which are well applied in fluorescent biosensing. Herein we developed a multifunctional probe based on the surface engineering of core-shell structure UCNPs with polyacrylic acid (PAA). The developed PAA/UCNPs probe could be highly selective to detect and respond to Cu2+ at different pH. Cu2+ could easily combine with the carboxylate anion of PAA to quench the fluorescence of UCNPs. Therefore, we creatively proposed a fluorescent array sensor (PAA/UCNPs-Cu2+), in which the same material acted as the sensing element by coupled with pH regulation for pattern recognition of 5 thiols. It could also easily identify the chiral enantiomer of cystine (l-Cys-and d-Cys), and distinguish their mixed samples with different concentrations, and more importantly, it could be combined with urine samples to detect actual level of homocysteine (Hcys) to provide a new solution for judging whether the human body suffers from homocystinuria. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
