An efficient catalyst for Pd-catalyzed carbonylation of aryl arenesulfonates |
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Authors: | Cai Chaoxian Rivera Nelo R Balsells Jaume Sidler Rick R McWilliams J Christopher Shultz C Scott Sun Yongkui |
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Affiliation: | Process Research, Merck Research Laboratories, Merck & Company, Inc., P. O. Box 2000, Rahway, NJ 07065, USA. chaoxian_cai@merck.com |
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Abstract: | Aryl carboxylic esters were synthesized by Pd-catalyzed carbonylation of aryl p-fluorobenzenesulfonates or -tosylates. A unique Josiphos ligand was discovered through high-throughput catalyst screening, which was the key for the successful carbonylation of various substrates. This catalyst is effective and works well for both electron-rich and electron-poor aryl arenesulfonates. Isolated yields of up to 90% were obtained for aryl p-fluorobenzenesulfonates and -tosylates. [reaction: see text] |
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