Mechanical characteristics of composites of polylactide and nanosized calcium phosphates formed in supercritical carbon dioxide |
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| Authors: | E. N. Antonov A. V. Popova I. I. Selezneva V. V. Trofimov A. Yu. Fedotov A. S. Fomin |
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| Affiliation: | 1.Institute of Laser and Information Technologies,Russian Academy of Science,Troitsk, Moscow oblast,Russia;2.Institute of Theoretical and Experimental Biophysics,Russian Academy of Sciences,Pushchino, Moscow oblast,Russia;3.Baikov Institute of Metallurgy and Materials Science,Russian Academy of Sciences,Moscow,Russia |
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| Abstract: | Composite materials for biomedical applications based on polylactide, a bioresorbable polymer, and nanosized calcium phosphate (hydroxyapatite) were produced using supercritical (SC) carbon dioxide. For composites with different polymer-to-mineral ratios, the bending stress-strain diagrams were investigated. The elasticity moduli of composites obtained in SC-CO2 from powdered bioresorbable polymer and bioactive nanoceramics ranged elastic modulus of natural bone. Experiments on adhesion of human embryonic fibroblasts demonstrated the suitability of generated samples for use in bone tissue scaffold engineering and regenerative medicine. |
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