Unexpectedly stable artificial duplex from flexible acyclic threoninol |
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Authors: | Asanuma Hiroyuki Toda Takasuke Murayama Keiji Liang Xingguo Kashida Hiromu |
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Institution: | Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan. asanuma@mol.nagoya-u.ac.jp |
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Abstract: | A new foldamer, acyclic threoninol nucleic acid (aTNA), has been synthesized by tethering each of the genetic nucleobases A, G, C, and T to d-threoninol molecules, which were then incorporated as building blocks into a scaffold bearing phosphodiester linkages. We found that with its fully complementary strand in an antiparallel fashion, the aTNA oligomer forms an exceptionally stable duplex that is far more stable than corresponding DNA or RNA duplexes, even though single-stranded aTNA is rather flexible and thus does not take a preorganized structure. |
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