The protein folding transition state: insights from kinetics and thermodynamics |
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Authors: | Travasso Rui D M Faísca Patrícia F N Rey Antonio |
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Institution: | Departamento de Física, Centro de Física Computacional, Universidade de Coimbra, Coimbra 3004-516, Portugal. rui@lca.uc.pt |
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Abstract: | We perform extensive lattice Monte Carlo simulations of protein folding to construct and compare the equilibrium and the kinetic transition state ensembles of a model protein that folds to the native state with two-state kinetics. The kinetic definition of the transition state is based on the folding probability analysis method, and therefore on the selection of conformations with 0.4
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