Artificial ribonucleases |
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Authors: | Niittymäki Teija Lönnberg Harri |
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Institution: | Department of Chemistry, University of Turku, FIN-20014, Turku, Finland. |
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Abstract: | Mimicking the action of enzymes by simpler and more robust man-made catalysts has long inspired bioorganic chemists. During the past decade, mimics for RNA-cleaving enzymes, ribonucleases, or, more precisely, mimics of ribozymes that cleave RNA in sequence-selective rather than base-selective manner, have received special attention. These artificial ribonucleases are typically oligonucleotides (or their structural analogs) that bear a catalytically active conjugate group and catalyze sequence-selective hydrolysis of RNA phosphodiester bonds. |
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