Short synthesis of the 6,6-spiroketal cores of spirofungins A and B |
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Authors: | Dias Luiz C de Oliveira Luciana G |
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Institution: | Instituto de Química, Universidade Estadual de Campinas, UNICAMP, C.P. 6154 13084-971, Campinas, SP, Brazil. ldias@iqm.unicap.br |
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Abstract: | reaction: see text] Initial efforts toward the total synthesis of the antifungal antibiotics spirofungins A and B are reported. A short and efficient synthesis of the C9-C20 6,6-spiroketal fragments of both compounds is described. This asymmetric approach uses a very efficient alkylation of a lithiated N,N-dimethylhydrazone followed by spiroketal formation under acidic conditions. |
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