| 稀土元素对腺嘌呤及鸟嘌呤单核苷酸的水解断裂作用 |
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| 引用本文： | 朱兵,李新民,赵大庆,吴亦洁,倪嘉缵. 稀土元素对腺嘌呤及鸟嘌呤单核苷酸的水解断裂作用[J]. 化学学报, 1996, 54(11): 1089-1093 |
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| 作者姓名： | 朱兵 李新民 赵大庆 吴亦洁 倪嘉缵 |
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| 作者单位： | 中国科学院长春应用化学研究所;中国科学院稀土化学与物理开放实验室 |
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| 摘 要： | 本文研究稀土元素对5'-腺嘌呤核苷酸(5'-AMP)和5'-鸟嘌呤核苷酸(5'-GMP)的水解断裂作用。空气中CeCl~3在pH 9，37℃能有效地水解断裂5'-AMP及5'-GMP,而其它三价稀土对5'-AMP和5'-GMP的水解断裂作用很小, 铈对5'-AMP的水解断裂速度大于5'-GMP。紫外吸收光谱实验结果表明反应体系中Ce(Ⅲ)部分被氧化成Ce(Ⅳ), Ce(Ⅳ)的氢氧簇合物是使5'-AMP和5'-GMP水解的活性组分。
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| 关 键 词： | 鸟嘌呤 断裂 寡核苷酸 稀土元素 腺嘌呤 水解作用 国家攀登计划基金 其它基金 |
Hydrolysis of aderosine monophosphate and guanosine monophosphate by lanthanides |
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| ZHU BING,LI XINMIN,ZHAO DAQING,WU YIJIE,NI JIAZUAN. Hydrolysis of aderosine monophosphate and guanosine monophosphate by lanthanides[J]. Acta Chimica Sinica, 1996, 54(11): 1089-1093 |
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| Authors: | ZHU BING LI XINMIN ZHAO DAQING WU YIJIE NI JIAZUAN |
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| Abstract: | The hydrolysis of adenosine-5'-monophosphate (5'-AMP) and guanosine-5'-monophosphate (5'-GMP) by lanthanides was investigated. 5'-AMP and 5'-GMP was efficiently hydrolyzed by cerium(Ⅲ) chloride under air at pH 9 and 37℃, and other lanthanides(Ⅲ) showed less efficiency at the same condition. The hydrolysis rate of 5'-AMP by cerium was greater than that of 5'-GMP. UV spectra showed that Ce(Ⅲ) was oxidized to Ce(Ⅳ) in the reaction mixture. The active species for the hydrolysis of 5'-AMP and 5'-GMP was ascribed to the Ce(Ⅳ) hydroxide cluster in the reaction mixture. |
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| Keywords: | GUANINE FRACTURE OLIGONUCLEOTIDE RARE ELEMENT ADENINE HYDROLYSIS |
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