Interaction of 1-(2-tetrahydrofuryl)-5-fluorouracil with sodium poly-α,L-glutamate |
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| Authors: | Nishida K Ando Y Mochinaga N |
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| Institution: | (1) Department of Chemistry, Tokyo University of Agriculture and Technology, Tokyo No-Ko Daigaku Kogakubu Koganei-shi, 184 Tokyo, Japan |
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| Abstract: | Summary The interaction of an anticancer drug, 1-(2-tetrahydrofuryl)-5-fluorouracil with sodium poly- ,L-glutamate in aqueous solution was studied with a spectral method and viscosity measurement. From the binding data, the molar change in enthalpy, entropy and the number of binding sites on polymer were calculated. The standard affinity of 1-(2-tetrahydrofuryl)-5-fluorouracil is about –10 kcal/ol with sodium poly-,L-glutamate. The affinity is also very high.With 6 figures and 2 tables |
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| Keywords: | Anticancer drug 1-(2-tetrahydrofuryl)-5-fluorouracil Sodium poly- " target="_blank">gif" alt="agr" align="BASELINE" BORDER="0"> L-glutamate Interaction Viscosity |
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