| Synthesis and Antibacterial Activity of New Tetracyclic Triazolo-thiadiazino Fluoroquinolones |
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| 引用本文： | Guo Qiang HU1*,Zhong Quan ZHANG1,Wen Long HUANG 2,Hui Bin ZHANG 2,Sheng Tang HUANG 2 1Medical College of Henan University,Kaifeng 475004 2 China Pharmaceutical University,Nanjing 210009. Synthesis and Antibacterial Activity of New Tetracyclic Triazolo-thiadiazino Fluoroquinolones[J]. 中国化学快报, 2004, 15(1) |
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| 作者姓名： | Guo Qiang HU1* Zhong Quan ZHANG1 Wen Long HUANG 2 Hui Bin ZHANG 2 Sheng Tang HUANG 2 1Medical College of Henan University Kaifeng 475004 2 China Pharmaceutical University Nanjing 210009 |
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| 作者单位： | Guo Qiang HU1*，Zhong Quan ZHANG1，Wen Long HUANG 2，Hui Bin ZHANG 2，Sheng Tang HUANG 2 1Medical College of Henan University，Kaifeng 475004 2 China Pharmaceutical University，Nanjing 210009 |
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| 摘 要： | Since nalidixic acid1 was first clinically used as a potent antibacterial agent, many analogues, such as bicyclic ciprofloxacin2, tricyclic ofloxacin3, have become an important class of therapeutical compounds. Recently, novel tetracyclic fluoroquinolones having a thiazolooxazine ring with potent antibacterial activity against both G+ and G- have been reported4. In order to find better antibacterial agents for our urgent research of the multidrug resistant (MDR)5, we herein describe a facil…
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Synthesis and Antibacterial Activity of New Tetracyclic Triazolothiadiazino Fluoroquinolones |
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| Guo Qiang HU,Zhong Quan ZHANG,Wen Long HUANG ,Hui Bin ZHANG ,Sheng Tang HUANG Medical College of Henan University,Kaifeng China Pharmaceutical University,Nanjing. Synthesis and Antibacterial Activity of New Tetracyclic Triazolothiadiazino Fluoroquinolones[J]. Chinese Chemical Letters, 2004, 15(1) |
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| Authors: | Guo Qiang HU Zhong Quan ZHANG Wen Long HUANG Hui Bin ZHANG Sheng Tang HUANG Medical College of Henan University Kaifeng China Pharmaceutical University Nanjing |
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| Affiliation: | Guo Qiang HU1*,Zhong Quan ZHANG1,Wen Long HUANG 2,Hui Bin ZHANG 2,Sheng Tang HUANG 2 1Medical College of Henan University,Kaifeng 475004 2 China Pharmaceutical University,Nanjing 210009 |
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| Abstract: | A series of novel 9-fluoro-10-(4-methylpiperazin-1-yl)-3-substituted-8-oxo-8H-[1,2,4] triazolo[3,4-b]thiadiazino[6,5,4-ij]quinoline-7-carboxylic acids was prepared by a facile synthetic method and the in vitro antibacterial activity against Gram-postive (G+) and Gram negative (G-) bacteria was primarily evaluated. |
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| Keywords: | Antibiotics tetracyclicquinolone synthesis antibacterial agents. |
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