首页 | 本学科首页   官方微博 | 高级检索  
     

PLA/PEG/PLA三嵌段共聚物载药纳米胶囊的制备及表征
引用本文:牛文强 傅国旗 吴俊丽 石可瑜 袁直 何炳林. PLA/PEG/PLA三嵌段共聚物载药纳米胶囊的制备及表征[J]. 高等学校化学学报, 2005, 26(7): 1369-1371
作者姓名:牛文强 傅国旗 吴俊丽 石可瑜 袁直 何炳林
作者单位:南开大学-天津大学联合研究院吸附分离功能高分子材料国家重点实验室, 南开大学高分子化学研究所 天津300071
基金项目:高等学校博士学科点专项科研项目
摘    要:用于药物控释体系的微胶束具有实心微球结构,药物分子主要吸附于微球表面,极易脱落,在释药初期有明显的突释效应;而微胶囊的药物主要集中于囊心部分,药物通过扩散作用以及高分子膜的降解而逐渐释放到环境中,因而更有利于药物分子平稳、缓慢地释放.对于自然界中能够自发形成微胶囊的小分子材料,其分子中往往具有一个较小的亲水部分和一个相对较大的憎水部分,

关 键 词:PLA/PEG/PLA三嵌段共聚物  双乳化溶剂蒸发法  纳米微胶囊  胰岛素  
文章编号:0251-0790(2005)07-1369-03
收稿时间:2004-08-17

Preparation and Characterization of Drug-loaded PLA/PEG/PLA Triblock Copolymer Nanocapsules
NIU Wen-Qiang,FU Guo-qi,WU Jun-li,SHI Ke-yu,YUAN Zhi,HE Bing-Lin. Preparation and Characterization of Drug-loaded PLA/PEG/PLA Triblock Copolymer Nanocapsules[J]. Chemical Research In Chinese Universities, 2005, 26(7): 1369-1371
Authors:NIU Wen-Qiang  FU Guo-qi  WU Jun-li  SHI Ke-yu  YUAN Zhi  HE Bing-Lin
Affiliation:N & J Joint Academy, The State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry, Nankai University, Tianjin 30071, China
Abstract:Biodegradable triblock copolymer PLA/PEG/PLA was synthesized by ring-opening bulk polymerization of D,L-lactide in the presence of poly(ethylene glycol) (PEG), in the molecular structure of which, the length of PEG and PLA chain segments was made to be quite different. Nanoparticles were prepared by using the copolymer via a double emulsion-evaporation technique. The paticles tended to form the configuration like capsules, i.e., the nanocapsules, because of the great size difference in PEG and PLA segments of the copolymer. Insulin, chosen as a model drug, was encapsulated into nanocapsules. The effect of preparation conditions on the size, insulin encapsulation efficiency, and in vitro drug release behavour of the nanoparticles were investigated. The experimental results show that the nanocapsules had a smooth spherical surface and the mean diameter was in the range from 180 nm to 350 nm, and the entrapment of insulin achieved up to 78.4. The drug-loaded nanocapsules released their content continuously, remarkably different from the corresponding micelles which gave a significant initial burst release followed by a slow release.
Keywords:PLA/PEG/PLA triblock copolymer  Double emulsion-solvent evaporation technique  Nanocapsule  Insulin  
本文献已被 CNKI 维普 万方数据 等数据库收录!
点击此处可从《高等学校化学学报》浏览原始摘要信息
点击此处可从《高等学校化学学报》下载全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号