Synthesis of 1-substituted (R,S)-8-(2-methoxy-5-methylphenyl)-3,3,9-trimethyl-2-azaspiro[4.5]deca-1,7-dien-6-ones |
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| Authors: | Shklyaev Yu V Nifontov Yu V Shashkov A S Firgang S I |
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| Institution: | (1) Ural Branch of the Russian Academy of Sciences, Institute of Technical Chemistry, 13 ul. Lenina, 614000 Perm, Russian Federation;(2) Russian Academy of Sciences, N. D. Zelinsky Institute of Organic Chemistry, 47 Leninsky prosp., 119991 Moscow, Russian Federation |
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| Abstract: | Reactions between p-methylanisole, isobutyraldehyde, and nitriles (acetonitrile, methyl thiocyanate, or ethyl cyanoacetate) in conc. H2SO4 yield 1-substituted (R,S)-8-(2-methoxy-5-methylphenyl)-3,3,9-trimethyl-2-azaspiro4.5]deca-1,7-dien-6-ones. |
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| Keywords: | nitrogen-containing spiroheterocycles p-methylanisole isobutyraldehyde nitriles Ritter reaction ortho-spiroheterocyclization alkylation |
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