Synthesis of rigid homo- and heteroditopic nucleobase-terminated molecules incorporating adenine and/or thymine |
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Authors: | Jacobsen Mikkel F Andersen Casper S Knudsen Martin M Gothelf Kurt V |
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Institution: | Centre for DNA Nanotechnology, Department of Chemistry, University of Aarhus, Langelandsgade 140, 8000 Aarhus C, Denmark. |
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Abstract: | A series of homo- and heteroditopic thymine- and/or adenine-terminated molecules incorporating rigid aryl or oligo(phenylene ethynylene) linkers has been efficiently synthesized. The key steps involved in the synthesis are the construction of the N-arylated nucleobases using the Chan-Lam-Evans-modified Ullman coupling and their further elaboration using the Sonogashira coupling. Furthermore, the synthesis of a rigid tripodal thymine derivative is reported. |
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