Electrocatalytic multicomponent assembling of isatins, 3-methyl-2-pyrazolin-5-ones and malononitrile: facile and convenient way to functionalized spirocyclic [indole-3,4′-pyrano[2,3-c]pyrazole] system |
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Authors: | Michail N. Elinson Alexander S. Dorofeev Fedor M. Miloserdov Gennady I. Nikishin |
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Affiliation: | (1) N. D. Zelinsky Institute of Organic Chemistry, Leninsky Prospect 47, 119991 Moscow, Russia |
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Abstract: | Electrochemically induced catalytic multicomponent transformation of isatins, 3-methyl-2-pyrazolin-5-ones and malononitrile in ethanol in an undivided cell in the presence of sodium bromide as an electrolyte results in the formation of spirooxindoles with fused functionalized pyrano[2,3-c]pyrazole system in 78–99} yields. The developed efficient electrocatalytic approach to medicinally relevant spirocyclic [indole-3,4′-pyrano[2,3-c]pyrazoles] is beneficial from the viewpoint of diversity-oriented large-scale processes and represents a novel example of facile environmentally benign synthetic concept for electrocatalytic multicomponent reaction strategy. |
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Keywords: | Electrocatalysis Multicomponent reactions Pyranopyrazole Spirooxindole Isatin C– H acids |
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