| 3-芳基-4-[4′(2,2,6,6-四甲基哌啶-1-氧)]-1,2,4-三唑啉-5-硫酮类的合成 |
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| 引用本文： | 张自义,施继成.3-芳基-4-[4′(2,2,6,6-四甲基哌啶-1-氧)]-1,2,4-三唑啉-5-硫酮类的合成[J].有机化学,1991(2). |
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| 作者姓名： | 张自义 施继成 |
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| 作者单位： | 兰州大学化学系兰州大学应用有机化学国家重点实验室，兰州大学化学系兰州大学应用有机化学国家重点实验室 甘肃，兰州，730000，甘肃，兰州，730000 |
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| 摘 要： | 前文指出,各种1,4-二取代的酰氨基硫脲可在碱性物质催化下脱水环化形成1,2,4-三唑啉-5-硫酮类杂环化合物,然而连接2,2,6,6-四甲基哌啶-1-氧自由基的酰氨基硫脲类化合物能否在相同条件下环化脱水形成类似结构的杂环化合物,迄今未见文献报道。各种3,4-二取代的1,2,4-三唑啉-5-硫酮杂环化合物具有广泛的生物活性,如抗菌,杀虫等,而2,2,6,6-四甲基哌啶-1-
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Synthesis of 3-Aryl-4-[4'-(2,2,6,6-tetramethyl-piperidine-1-oxyl)]-1,2,4-triazoline-5-thiones |
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| ZHANG Zi-Yi SHI Ji-Chen.Synthesis of 3-Aryl-4-[4'-(2,2,6,6-tetramethyl-piperidine-1-oxyl)]-1,2,4-triazoline-5-thiones[J].Chinese Journal of Organic Chemistry,1991(2). |
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| Authors: | ZHANG Zi-Yi SHI Ji-Chen |
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| Abstract: | In this paper the synthesis of eight new 3-aryl-4-(4'-2,2,6,6-tetramethyl-pipe-ridine-1-oxyl)-1,2,4-triazoline-5-thiones and the characterization of their structure werereported.Preliminary pharmacodynamic experiments of these compounds showed that mostof them possess inhibiting effect on Bacillus subitilis,Escherichia,Proteus vuigaris and Sta-phylococcus aurreus. |
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| Keywords: | spin label piperidine nitroxide 1 2 4-triazoline-5-thione |
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