Fluorescence enhancement of coumarin-6-sulfonyl chloride amino acid derivatives in cyclodextrin media. |
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| Authors: | S M Al-Kindy F E Suliman A A Al-Hamadi |
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| Institution: | College of Science, Department of Chemistry, Muscat, Sultanate of Oman. alkindy@squ.edu.om |
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| Abstract: | Coumarin-6-sulfonyl (6-CS) amino acid derivatives form inclusion complexes with a- and /-cyclodextrins (CD) in aqueous solution. The stoichiometry of the inclusion complex and the equilibrium constant were investigated. Using a fluorescence technique and alanine-beta-CD as a model, a 1:2 guest-host complex was established, and K = 4.7 x 10(5) mol(-2) l(2) was obtained. Fluorescence enhancement was observed for all derivatives studied, with glycine exhibiting a greater enhancement, and tyrosine showing the least. The stability of the inclusion complex was found to depend on the respective sizes of the guest-host complex and their interaction. |
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