Model studies toward the synthesis of the bioactive diterpenoid, harringtonolide |
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Authors: | O'Sullivan Timothy P Zhang Hongbin Mander Lewis N |
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Institution: | Department of Chemistry, University College Cork, Cork, Ireland. tim.osullivan@ucc.ie |
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Abstract: | In model studies towards the synthesis of harringtonolide, the construction of the tropone moiety via arene cyclopropanation was investigated. The installation of the lactone ring was accomplished by way of a Diels-Alder cycloaddition of various indenones and a-pyones. The incorporation of the key bridge methyl group and subsequent control of its stereochemistry is also outlined. |
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