Evolution of enzymes and pathways for the biosynthesis of cofactors |
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| Authors: | Holliday Gemma L Thornton Janet M Marquet Andrée Smith Alison G Rébeillé Fabrice Mendel Ralf Schubert Heidi L Lawrence Andrew D Warren Martin J |
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| Institution: | European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, UK CB10 1SD. gemma@ebi.ac.uk |
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| Abstract: | The evolution of metabolic pathways is discussed with reference to the biosynthesis of a number of vitamins and cofactors. Retrograde and patchwork models are highlighted and their relevance to our knowledge of pathway processes and enzymes is examined. Pathway complexity is explained in terms of the acquisition of broad specificity enzymes. |
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