Asymmetric deprotonation-substitution of N-Pop-benzylamines using [RLi/(-)-sparteine]. Enantioselective sequential reactions and synthesis of N-heterocycles |
| |
| Authors: | Oña-Burgos Pascual Fernández Ignacio Roces Laura Torre-Fernández Laura García-Granda Santiago López-Ortiz Fernando |
| |
| Institution: | Area de Química Orgánica, Universidad de Almería, Carretera de Sacramento s/n, 04120 Almería, Spain. |
| |
| Abstract: | Pop-directed asymmetric deprotonation of benzylic amines using n-BuLi/(-)-sparteine] provides an efficient method for the synthesis of chiral NC alpha and NC alpha,alpha' derivatives with total selectivity with respect to competing allylic and ortho lithiation. The method described herein offers a straightforward route of accessing chiral N-Pop-protected nitrogen heterocycles. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
