Cyclopenicillone, a unique cyclopentenone from the cultures of Penicillium decumbens |
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| Authors: | Lin Sheng Shi Ting Chen Ke-Yv Zhang Zhong-Xiao Shan Lei Shen Yun-Heng Zhang Wei-Dong |
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| Institution: | Department of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China. |
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| Abstract: | Cyclopenicillone (1), possessing a unique 2,5-dimethylcyclopent-2-enone carbon skeleton, has been isolated from the cultures broth of the fungus Penicillium decumbens. The structure and absolute configuration of 1 were elucidated using a combination of NMR spectroscopy, CD data and computational approaches. Cyclopenicillone (1) demonstrated a dose-dependent (10-100 μM) inhibition against LPS-induced NO production in RAW264.7 macrophages. |
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