Preparation and Fungitoxicity of Some Dibromo-8-quinolinols |
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Authors: | Herman Gershon Donald D Clarke John J McMahon Muriel Gershon |
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Institution: | (1) Department of Chemistry, Fordham University, Bronx, NY 10458-9993, USA, US;(2) New York Botanical Garden, Bronx, NY 10458-9993, USA, US |
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Abstract: | Summary. 2,5-, 3,5-, 3,6-, 3,7-, 4,5-, 5,6-, 5,7-, and 6,7-dibromo-8-quinolinols were prepared and tested against six fungi (Aspergillus niger, Aspergillus oryzae, Myrothecium verrucaria, Trichoderma viride, Mucor cirinelloides, and Trichophyton mentagrophytes) in Sabouraud dextrose broth. Most of the compounds were strongly antifungal, inhibiting five of the fungi below 1μg/cm3, but were somewhat less fungitoxic than the corresponding chloro analogues. M. cirinelloides was not inhibited by any of the compounds except 4,5-dibromo-8-quinolinol. This high level of fungitoxicity is attributed
to intramolecular synergism.
Received December 28, 2000. Accepted (revised) February 3, 2001 |
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Keywords: | , ,Dibromo-8-quinolinols, Antifungal activity, Intramolecular synergism, |
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