Eta(1)-2-pyrone metal carbonyl complexes as CO-releasing molecules (CO-RMs): a delicate balance between stability and CO liberation |
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| Authors: | Fairlamb Ian J S Lynam Jason M Moulton Benjamin E Taylor Ian E Duhme-Klair Anne K Sawle Philip Motterlini Roberto |
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| Institution: | Department of Chemistry, University of York, Heslington, York, UK, YO10 5DD. ijsf1@york.ac.uk |
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| Abstract: | An evaluation of the CO releasing ability of iron(II) and molybdenum(II) complexes has facilitated the discovery of the most rapid CO releaser, namely Mo(CO)(3)(eta(5)-C(5)H(5))(eta(1)-{O}-C{=O}-O-CMe=CH-COMe=CBr)]BF(4) (CORM-F10), reported to date. The rate of CO release is related to the overall solution phase stability of the transition metal carbonyl complex. The cytotoxicity and vasodilatory properties of CORM-F10 have been determined. |
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