| 单个心肌细胞中随机钙火花诱发的钙离子螺旋波 |
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| 引用本文： | 白永强,朱星.单个心肌细胞中随机钙火花诱发的钙离子螺旋波[J].物理学报,2012,61(15):158203-158203. |
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| 作者姓名： | 白永强 朱星 |
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| 作者单位： | 1. 东北石油大学电子科学学院,黑龙江省高校校企共建测试计量技术及仪器仪表工程研发中心,大庆163318
2. 北京大学物理学院,人工微结构与介观物理国家重点实验室,北京100871／国家纳米科学中心,北京100080 |
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| 基金项目： | 黑龙江省自然科学基金(批准号: A200911)和国家重点基础研究发展计划(973计划)(批准号: 2007CB936800)资助的课题. |
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| 摘 要： | 利用改进的描述单个心肌细胞内钙信号的离散的fire-diffuse-fire模型和相分析方法, 模拟研究了钙火花随机释放特性对钙离子螺旋波的诱导激发作用, 研究结果表明, 适当频率的钙火花可以在静息心肌细胞中诱导产生钙离子螺旋波; 时序和空间不同的钙火花引起的相奇点的出现, 是产生螺旋波的关键; 系统相奇点的个数与钙火花频率相关, 并且对于固定系统有极限值.
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| 关 键 词： | 心肌细胞 钙火花 钙离子螺旋波 相奇点 |
| 收稿时间： | 2012-03-19 |
Calcium ion spiral wave induced by random calcium ion sparks in single heart cell |
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| Bai Yong-Qiang,Zhu Xing.Calcium ion spiral wave induced by random calcium ion sparks in single heart cell[J].Acta Physica Sinica,2012,61(15):158203-158203. |
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| Authors: | Bai Yong-Qiang Zhu Xing |
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| Institution: | 1. School of Electronic Science, Northeast Petroleum University, The University-enterprise R & D Center of Measuring and Testing Technology & Instrument and Meter Engineering in Heilongjiang Province, Daqing 163318, China;2. School of Physics, State Key Laboratory for Artificial Microstructure and Mesoscopic Physics, Peking University, Beijing 100871, China;3. National Center for Nanoscience and Technology, Beijing 100080, China |
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| Abstract: | Calcium ion spiral wave induced by random released calcium ion sparks in single heart cell is studied using the improved discrete fire-diffuse-fire model and phase analysis method. The results show that calcium ion spiral wave can be excited in resting heart cell by calcium ion sparks at an appropriate release frequency. The key of the generation of calcium ion spiral wave is the emergence of the phase singularity caused by the calcium sparks in the different time and space sequences. The number of phase singularity is exponentially linked with calcium ion spark frequency, and has the limit in a fixed system. |
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| Keywords: | heart cell Ca2+ spark Ca2+ spiral wave phase singularity |
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