N,N,N^{prime },N^{prime }-Tetrabromobenzene-1,3-disulfonamide and poly(N-bromo-N-ethylbenzene-1,3-disulfonamide) as new and efficient catalysts for the synthesis of highly substituted 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives |
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Authors: | Ramin Ghorbani-Vaghei Mostafa Amiri Rahman Karimi-Nami Zahra Toghraei-Semiromi Mehdi Ghavidel |
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Affiliation: | 1. Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali-Sina University, 65174, Hamedan, Iran 2. Department of Chemistry, Faculty of Science, Urmia University, 57154, Urmia, Iran
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Abstract: | Various mono and bis-1,6-dihydropyrazine-2,3-dicarbonitrile derivatives were efficiently synthesized by reacting 2,3-diaminomaleonitrile (DAMN), isocyanides and ketones in the presence of a catalytic amount of $N,N{,}N^{prime }{,}N^{prime }$ -tetrabromobenzene-1,3-disulfonamide [TBBDA] and poly( $N$ -bromo- $N$ -ethylbenzene-1,3-disulfonamide) [PBBS] in EtOH/H $_{2}$ O at ambient temperature. Graphic abstract $N,N,N^{prime },N^{prime }$ -Tetrabromobenzene-1,3-disulfonamide and poly( $N$ -bromo- $N$ -ethylbenzene-1,3-disulfonamide) as new and efficient catalysts for the synthesis of highly substituted 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives. | |
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