Cascade reaction of isatins with heterocyclic ketene aminals: synthesis of imidazopyrroloquinoline derivatives |
| |
| Authors: | Yu Fuchao Yan Shengjiao Hu Ling Wang Yongchao Lin Jun |
| |
| Affiliation: | Key Laboratory of Medicinal Chemistry for Natural Resources (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China. |
| |
| Abstract: | A concise and efficient route for the synthesis of highly substituted imidazopyrroloquinoline derivatives by simply refluxing a reaction mixture of different types of isatins and heterocyclic ketene aminals (HKAs) by acetic acid was developed. This method is suitable for combinatorial and parallel syntheses in drug discovery; consequently, a library of highly substituted imidazopyrroloquinoline derivatives was rapidly constructed using the present protocol. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
