Quantitative genotyping of single nucleotide polymorphism by single-molecule multi-color fluorescence resonance energy transfer |
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| Authors: | Koh Hye Ran Han Kyu Young Jung Jiwon Kim Seong Keun |
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| Institution: | Department of Chemistry, Seoul National University, Seoul 151-747, Korea. |
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| Abstract: | We developed a new single nucleotide polymorphism (SNP) genotyping method based on single-molecule multi-color fluorescence resonance energy transfer (FRET). We demonstrated that this new method uses less than 1 fmol of sample and is also highly quantitative with a detection level of 1% or lower in the minor allele fraction. |
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